Based on RT‐qPCR and Western blot analysis, compared with HNSCC cells following NC treatment, HOTAIR and STC2 levels in HNSCC cells following HOTAIR treatment were increased, while HOTAIR level was increased, but STC2 levels remained statistically similar in HNSCC cells treated with HOTAIR + si‐STC2 (Figure 8A‐C). This evidence concerns the gene STC2 and head and neck squamous cell carcinoma.