In consistency with our results, miR‐206 inhibited tumour growth and metastasis in GC via targeting STC2.34 The impact of activated PI3K/AKT signalling pathway is significant in various fundamental biological activities.35 Likewise, the PI3K/AKT signalling pathway regulated cell biological functions in HNSCC.36 Furthermore, overexpressed miR‐206 suppressed lung cancer cell migration and invasion via inhibition of the PI3K/AKT/mTOR signalling pathway.37 This evidence concerns the gene STC2 and head and neck squamous cell carcinoma.