STAT3 and neoplasm: The tumor-promoting activities of IL-6 are manifold and include the evasion of growth suppression by regulating the TP53 gene [19], mediating resistance against cell death [20, 21], increasing stemness of tumor cells [22, 23], and mediating tumor invasion and metastasis through EMT via the JAK/STAT3/Snail signaling pathway [24, 25].