Lapatinib, afatinib, and neratinib, all HER2 tyrosine kinase inhibitors, block functional signaling but are associated with poor clinical efficacy in a limited number of uterine cervix cancer patient-treated women [4 [5%] of 78 and 0 [0%] of 2, respectively (49, 50)]. The gene discussed is ERBB2; the disease is cervical cancer.