IFNG and cancer: In both vitro and vivo, IFN-γ produced by cytotoxic T lymphocytes (CTLs) could induce G0/G1 arrest and the dormancy of tumor-repopulating cells (TRCs), which refer to a subpopulation of cancer cells with the capacity of self-renewing and highly tumorigenic in several types of murine and human tumors, such as melanoma and liver cancer.