However, in the EcN (p53), EcN (Tum-5), and EcN (Tum 5-p53)-treated groups, the expression of Ki-67 in the tumor region decreased, and only a few cells in the tumor region of EcN (Tum 5-p53) group showed red Ki-67 (Fig. 7b and d). Here, TP53 is linked to neoplasm.