Genome editing based on programmable nucleases is a molecular process that uses clustered regularly interspaced short palindromic repeats systems (CRISPR) with Caspase 9 (Cas9) guiding enzymes and has been used to introduce the catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) associated cardiac ryanodine receptor 2(RYR2) mutation in healthy wild iPSCs [19]. This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia 1.