DYSF and hereditary disease: Two of these protein family members, Dysferlin (DYSF) and Otoferlin (OTOF), are well known in connection to human genetic disorders: DYSF gene was linked to limb-girdle muscle dystrophy 2B (LGMD2B) (MIM#253601) and Miyoshi myopathy (MIM#254130), while OTOF was reported as a causative gene for non-syndromic hearing loss (MIM#601071).