Eventhough DYSF pathogenic variants are mainly associated with LGMD2B and Miyoshi myopathy, subtle cardiac dysfunction have also been described in patients with DYSF mutations (Wenzel et al., 2007; Choi et al., 2010; Nishikawa et al., 2016), and supported by a number of experimental studies (Han et al., 2007; Wang et al., 2015). Here, DYSF is linked to Miyoshi myopathy.