Shk1 binding protein 1 (SKB1/AtPRMT5), which catalyzes the symmetric dimethylation of histone H4R3 (H4R3sme2), was identified to be involved in iron homeostasis in Arabidopsis, while the SKB1 lesion mutant exhibited higher iron content in shoots and more tolerance to iron deficiency, compared to wild type (Fan et al., 2013). The gene discussed is PRMT5; the disease is nutritional disorder.