Chymase has also been suggested to exert pathological roles in multiple diseases such as cancers, cardiovascular diseases, inflammatory lung diseases (idiopathic pulmonary fibrosis, COPD), renal diseases (diabetic nephropathy, hypertensive nephropathy, rejected kidney allograft), preeclampsia, skin keloid, and atopic dermatitis (220, 221, 236–243). The gene discussed is CMA1; the disease is atopic eczema.