Chymase has also been suggested to exert pathological roles in multiple diseases such as cancers, cardiovascular diseases, inflammatory lung diseases (idiopathic pulmonary fibrosis, COPD), renal diseases (diabetic nephropathy, hypertensive nephropathy, rejected kidney allograft), preeclampsia, skin keloid, and atopic dermatitis (220, 221, 236–243). This evidence concerns the gene CMA1 and diabetic kidney disease.