In this regard, CD4+ T cells from subjects carrying the autoimmunity-associated SNP rs1893217 show decreased expression of PTPN2, impaired signaling through the β chain of the IL-2 receptor, decreased phosphorylation of STAT5 and reduced expression of FOXP3 in response to IL-2 (137). The gene discussed is PTPN2; the disease is Autoimmunity.