It has been suggested that C-terminal binding protein 1 (CTBP1), complexin 1 (CPLX1), and phosphatidylinositol glycan anchor biosynthesis class G (PIGG) are possible candidates for developmental delay, intellectual disabilities, and seizures in WHS patients (Zollino et al., 2014). This evidence concerns the gene CTBP1 and Wolf-Hirschhorn syndrome.