TFEB and proteostasis deficiencies: Apparently, this decreased TFEB activity and autophagic impairment play an important pathogenic role in the advanced stage of cardiac proteinopathy because rescue effects from either viral delivery of TFEB to the heart at the advanced disease stage or germ-line transgenic enhancement of cardiac autophagy on mouse models of CryABR120G-based proteinopathy had been reported by others (Bhuiyan et al., 2013; Ma et al., 2019).