ANA-12 has been successfully used to target TrkB in preclinical studies of other types of tumors, including lung cancer, Ewing sarcoma, glioblastoma, oral squamous carcinoma, and leukemia (Polakowski et al., 2014; Sinkevicius et al., 2014; Heinen et al., 2016; Pinheiro et al., 2017; Moriwaki et al., 2018). This evidence concerns the gene NTRK2 and lung cancer.