Given that BDNF/TrkB pathway is implicated in the pathogenesis and prognosis of a wide variety of malignancies, including neuroblastoma, glioblastoma, head and neck, breast, lung, and pancreas tumors as well as leukemia, being associated with promotion of proliferation, migration, resistance to anoikis and resistance to chemotherapy (Thiele et al., 2009; Roesler et al., 2011; Radin and Patel, 2017; Meng et al., 2019), here we investigated the potential role of TrkB inhibition in experimental MB. The gene discussed is NTRK2; the disease is leukemia.