HIF1A and myocardial ischemia: Previous studies showed that ginsenoside Rg3 could inhibit tumor angiogenesis by decreasing the expression of HIF-1 in various cancers, whereas ginsenoside Rg1 might inhibit myocardial ischemia and reperfusion injury by activating HIF-1 (Chen et al., 2010; Yuan et al., 2019).