During the cellular adaptation to hypoxic stress, PI3K/AKT/mTOR and MAPK signaling pathways are involved in hypoxia-induced tumor angiogenesis by various growth factors that bind to toll-like receptors (TLRs), alarmin receptors, receptor tyrosine kinases, and G protein–coupled receptors on cell surface, which may also activate HIF-1 (De Francesco et al., 2018). Here, HIF1A is linked to neoplasm.