For example, physiological angiogenesis in embryonic development requires activating the VEGF pathway, whereas hypoxia-induced angiogenesis such as tumor angiogenesis can also induce angiogenesis by recruiting myeloid cells and upregulate alternative vascular growth factors in addition to VEGF, such as fibroblast growth factor (FGF) and placental growth factor (PlGF). The gene discussed is PGF; the disease is neoplasm.