IL1B and colitis: Treatment with recombinant proteins was ineffective in attenuating DSS-induced colitis, only cyclosporine being able to mitigate clinical severity and colonic neutrophil recruitment; at variance, blockade of EphB/ephrin-B signaling markedly lowered both the local and systemic inflammatory responses elicited by TNBS, improving health conditions and counteracting colonic changes, leukocytes enrolment, and, accordingly IL-1β production.