In another study, exogenous administration of Shh improved the behavioral score of rats with cerebral I/R, reduced the volumes of cerebral infarction, and promoted the angiogenesis of ischemic peripheral tissues and the colonization of neural stem cells, and cyclopamine abrogated the neuroprotective effect of Shh (Huang et al., 2013). The gene discussed is SHH; the disease is brain infarction.