VEGFA and cancer: Lactate that enters into oxygenated endothelial cells and oxidative cancer cells via MCT1 promotes angiogenesis as it acts as a hypoxia-mimetic that activates the two transcription factors, hypoxia-inducible factor-1α (HIF-1α) and nuclear factor-κB (NF-κB), thereby stimulating the production of proangiogenic agents, like vascular endothelial growth factor (VEGF), basic fibroblast growth factor, and interleukin-8 (IL-8) [35].