APC and small intestine neoplasm: Since Bcl-G is also highly expressed by epithelial cells of the small intestine in adult mice (Fig. 3a), we crossed Bcl-g−/− mice to ApcMin/+ mice, which carry a germline truncation in Apc resulting in the development of small intestinal tumors following the spontaneous loss of heterozygosity of the WT Apc allele [17].