After adjustment for age, gender, tumour location, bowel obstruction, and MOSAIC risk group, CEA >2.35 ng/mL was still significantly associated with DFS (HR 1.49, 95% CI 1.10–2.00; P = 0.009) and OS (HR 1.90, 95% CI 1.33–2.72; P < 0.0001; Table 2 and Supplementary Table S1). The gene discussed is CEACAM5; the disease is neoplasm.