Information on the patients’ age, family history of BC, height, weight, body-mass-index (BMI), age of menarche and menopause, number of pregnancies, smoking habits, grade, infiltration of the blood vessels, nerves, skin or nipple, pathology evaluation, tumor diameter, status of estrogen receptors (ER), progesterone receptors (PR), HER2/neu, and lymph node metastasis (Supplementary Table 3) was also available. This evidence concerns the gene ESR1 and metastatic malignant neoplasm in the lymph nodes.