Using our data set derived from skeletal muscle tissue extracts from FKRP-deficient mice treated with AAV9-hFKRP and the respective positive (C57BL/6) and negative (FKRPP448L) controls, we have been able to expand the current metabolic footprint of musculoskeletal disorders and identify new potential candidate biomarkers in skeletal muscle associated with FKRP deficiency and age-related muscle pathology. The gene discussed is FKRP; the disease is musculoskeletal system disorder.