Mutations in one of the genes involved, FKRP (OMIM 606596), cause rare forms of limb-girdle muscular dystrophy (LGMD) with a broad spectrum of clinical manifestations characterized by progressive weakness and degeneration of the skeletal muscles that may include some cardiovascular and/or neurological defects3–6. Here, FKRP is linked to limb-girdle muscular dystrophy.