In brief, Propranolol-treated primary cultured hemangioblastoma (HB) cells decreased the RNA and protein expression levels of HIF-1α and HIF-2α, and therefore the pro-angiogenic and HIF-1α targets such us Endoglin, VEGF, EPO, and SOX. Moreover, VEGF and miR210 plasma levels from treated patients were reduced after treatment with Propranolol19,21. This evidence concerns the gene HIF1A and hemangioblastoma.