YAP1 and familial pancreatic carcinoma: We found LIF, but not IL-6, suppressed Hippo pathway in human PDAC cells, as evidenced by increased YAP/TAZ-TEAD transactional activities and increased expression of YAP1-targeted genes CNTF and ANKRAD. Neutralization of LIF or LIF knockdown led to increased phosphorylation of YAP at Ser127 in both human and mouse pancreatic cancer cell lines.