Doxycycline-induced expression of shRNA against LIF increased phosphorylation of YAP at Ser127, which caused its cytoplasmic retention for subsequent degradation13,14, and activated multiple Hippo-signaling pathway components, including LATS1 and MOB1, in human pancreatic cancer cells15 (Fig. 5d). This evidence concerns the gene YAP1 and familial pancreatic carcinoma.