The proposed electrostatically-driven head-to-tail interface encompasses several residues mutated in patients with Dilated Cardiomyopathy (DCM-CD) or Emery-Dreifuss, Limb-Girdle and Congenital Muscular Dystrophies (EDMD, LGMD1B, CMD). The gene discussed is LMNA; the disease is congenital muscular dystrophy.