DPP4 and infection: We also investigated the protective efficacy of 7D10-H against infection of pseudotyped MERS-CoV using R26-hDPP4 mice model with a human DPP4 inserted into the Rosa26 locus by CRISPR/Cas9, which could also been productively infected by high-titer MERS-CoV pseudovirus, with effects comparable to the authentic infection28.