Following a previous comparison of gene expression profiles between gliomas with different grades that revealed frequent overexpression of insulin-like growth factor binding protein 2 (IGFBP2) in glioblastomas [12], Yuan et al. [11] set out to investigate IGFPB2 mRNA levels in a larger cohort of glioblastomas. Here, IGFBP2 is linked to glioblastoma.