c-Myc is therefore vulnerable to dysregulation through gene amplification, chromosome translocation, viral insertion, mRNA and protein destabilization, and variations in protein expression levels, each of which contribute to its involvement in more than half of human cancers (Bernasconi et al. 2000; Gabay et al. 2014; Kalkat et al. 2017). The gene discussed is MYC; the disease is cancer.