Lipid-anchored Ras small GTPases (including isoforms H-Ras, N-Ras, splice variants K-Ras4A, and K-Ras4B) localize to the cell PM, directly activate MAPK cascade, regulate cell growth/proliferation, and are major drivers of ∼1/3 of all human cancer (Fig 1A) (19–21). This evidence concerns the gene KRAS and cancer.