The mRNA levels of GADD45B and PMAIP1 were significantly decreased by TFAP2C overexpression in WI-26 VA4 cells (Fig. 3a) but were increased by treatment of TFAP2C siRNA in the four human NSCLC cell lines (Fig. 3b–e). This evidence concerns the gene PMAIP1 and non-small cell lung carcinoma.