The results of the present study have shown that TFAP2C can contribute to NSCLC tumorigenesis via downregulation of many tumor suppressors including GADD45B, PMAIP1, XAF1, CYR61, IL24, ATF3, DLC1, RHOB, and TNFAIP3. This evidence concerns the gene XAF1 and non-small cell lung carcinoma.