In particular, growth arrest and DNA-damage-inducible beta (GADD45B) and phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) were downregulated by TFAP2C-overexpressing NSCLC cells, which contributed to NSCLC cell proliferation and motility. Here, PMAIP1 is linked to non-small cell lung carcinoma.