Additionally, in other tumor types, dual blockade of TGFβ and PD-1 in a mouse model of T cell exclusion induced immune-mediated tumor regression [18] and in a mouse model of colorectal cancer, blockade of TGFβ signaling rendered tumors susceptible to antibodies targeting PD-1/PD-L1 [19]. The gene discussed is CD274; the disease is neoplasm.