LEF1 and cancer: It has also been reported that the Wnt signaling pathway regulates cancer stem cell-like properties and contributes to the tumorigenic properties of many cancers, including breast cancer, esophageal cancer, etc. As a downstream mediator of the Wnt signaling pathway, LEF1 is also essential for stem cell maintenance and organ development in addition to its role in epithelial-mesenchymal transition (EMT) by activating the transcription of markers [15, 16].