At the same time, the mesenchymal maker vimentin and the EMT regulator Snail were significantly upregulated, while the epithelial marker E-cadherin was downregulated in HCC cells (MHCC97L, HepG2) co-cultured with M2 macrophages (Fig. 2i). The gene discussed is SNAI1; the disease is hepatocellular carcinoma.