The identified regulatory hotspots included HLA-DQA1, HLA-DQB1, HLA-DQB2, HLA-DRB1, HLA-DRB5, and ZFP57. HLA is known to be associated with various human diseases, including rheumatoid arthritis, multiple sclerosis, Crohn’s disease, type 1 diabetes (T1D), and HIV [57]. This evidence concerns the gene HLA-DRB5 and Crohn disease.