Furthermore, osteoclast markers including TRAP, cathepsin K, and nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) were upregulated when osteoclast precursors were co-cultured with IL-17-prestimulated RA synovial fibroblasts, and SKI306X reduced their expression (Figure 5B). The gene discussed is CTSK; the disease is rheumatoid arthritis.