Indeed, tumor buds have been shown to have reduced E‐Cadherin expression, to lose membrane β‐catenin expression and to overexpress EMT associated biomarkers like zinc finger E‐box-binding homeobox 1 and 2 (ZEB1 and ZEB2), SNAIL and N-Cadherin [24,25,26,27]. This evidence concerns the gene CDH1 and neoplasm.