In particular, our transcriptome study [49] identified the top three upregulated genes in the ME/CFS group, asIL8, NFKBIA and TNFAIP3 (see Figure 1), all of which are early-responders to Tumour Necrosis Factor (TNF)-induced Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation [51]. This evidence concerns the gene TNF and myalgic encephalomeyelitis/chronic fatigue syndrome.