NFKB1 and cancer: The previous studies have demonstrated that transcription factors, for instance, NF-κB and signal transducer and activator of transcription 3 (STAT3), inflammatory enzymes including matrix metalloproteinase-9 (MMP-9) and cyclooxygenase-2 (COX-2), and inflammatory cytokines such as interleukins (IL)-1, -6, -8, and tumor necrosis factor alpha (TNF-α) are the key molecular mediators for inflammation-induced cancer cell proliferation, metastasis, angiogenesis, invasion, and inhibition of apoptosis [32].