Co-treatment with curcumin (10 μM) and cisplatin (10 μM) has shown a potent synergistic effect by activating caspase-3 and upregulating phospho-mitogen-activated protein kinase (p-MEK) and phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2) signaling in bladder cancer cell lines (253J-Bv and T24) compared to curcumin or cisplatin alone [101]. The gene discussed is MAPK3; the disease is urinary bladder carcinoma.