The finding that GE is delayed in a relevant proportion of young asymptomatic T1DM patients and that it impacts the magnitude and the “shape” of PP glycemic response has important implications for the management of pre-prandial insulin; in fact, a delayed GE can result in a mismatch between PP glucose elevation and the timing of insulin action, with consequent high variability in PP glucose profile and, possibly, increased risk of hypoglycemia. This evidence concerns the gene INS and Hypoglycemia.