In this line, Huang et al. [137] found several metabolic pathways where prenylflavonoid xantuhumol can be engaged as protective in some neurodegenerative diseases, such as Alzheimer’s (e.g. through inhibiting the Aβ accumulation and APP processing, and inducing amelioration of tau hyperphosphorilation via PP2A, GSK3β pathways in N2a/APP cells). Here, APP is linked to neurodegenerative disease.