We initially screened these mi-RNAs for their ability to reduce the IC50 values to 5-FU (in a similar level that ARRDC3 reduces IC50 to 5-FU) and found that miR-200b-3p (miR-200b from now on) was most effective among those tumor suppressing miRNAs listed in Figure 3A in sensitizing MDA-MB-231 cells to 5-FU by lowering IC50 value from 28.65 to 9.59 μM (Figure 3B). Here, ARRDC3 is linked to neoplasm.