Interestingly, A-type var transcripts, particularly those encoding the EPCR-binding variant PFD0020c/PF3D7_0400400, were found to be among the most abundant in samples from malaria-naïve volunteers but were rarely detectable in samples from ‘non-controllers’ and absent in parasites infecting the group of ‘controllers’ (Fig 2, Fig 3A). The gene discussed is PROCR; the disease is malaria.