Levels of transcripts encoding EPCR-binding PfEMP1 relative to the sbp1 (skeleton binding protein 1) control gene were substantially higher in malaria-naïve than in lifelong malaria-exposed adults (Mann-Whitney U test, p<0.001) with median expression of 4.0 (range: 0.0–24.2) in the malaria-naïve group, 0.1 (range: 0.0–7.5) for ‘non-controller’ and 0.0 (range: 0–15.8) for ‘controller’. The gene discussed is PROCR; the disease is malaria.