Levels of serum PRO-C3 significantly associated with liver fibrosis measured by Fibroscan (rho = 0.289; p = 0.0005) (Fig 2A), bilirubin (rho = 0.196; p = 0.022) and APRI score (rho = 0.206; p = 0.0156) (Fig 2B). This evidence concerns the gene C3 and Hepatic fibrosis.