Th2 cytokines interleukin (IL)-4 and IL-10 were found to be mainly expressed while Th1 cytokine interferon γ (INF-γ) was only expressed in 1 out of 3 patients [15], moreover, Mhmoud and her associates determined the association between Th2 cytokine namely IL-10 in the granuloma caused by M. mycetomatis. This evidence concerns the gene IL10 and Granuloma.