NNMT KD has similarly been associated with the inhibition of proliferation and/or metastasis of oral squamous carcinoma, renal clear cell carcinoma cells, Panc‐1 pancreatic cancer cells, etc. Intriguingly, we detected lower NNMT levels in HCC tissues relative to normal adjacent tissues in agreement with previous report (Aksoy et al., 1994). The gene discussed is NNMT; the disease is familial pancreatic carcinoma.