KCNJ5 and hypoalphalipoproteinemia, primary, 1: Serum and urinary 18-hydroxycortisol, 18-oxocortisol, and 18-oxo-THF excretion are highest in FHA type 1 (= GRA, see “Glucocorticoid-remediable aldosteronism” above) (124, 173) and FHA type 3 (germline KCNJ5 mutations) (113); they also tend to be higher in APA than in bilateral hyperaldosteronism, albeit with considerable overlap (115).