However, more and more functional studies on MPL mutations have indicated that not all of atypical MPL mutations are the causative alterations in MPN pathology.15 These data attracted our attention that noncanonical MPL mutants discovered in patients with TN‐MPNs in clinic need to be further analyzed to verify whether they are real driver mutations in MPN pathology. This evidence concerns the gene MPL and myeloproliferative disorder.