F8 and Venous thrombosis: One main point up for debate is the relationship and the (individual) cause and effect of either VWF and/or FVIII on thrombosis incidence, as one study found VWF to be an independent risk factor,27 whereas another found the correlation of VWF with VTE to be largely explained by FVIII in multivariable analysis.23 Both studies were performed in non‐cancer patients.