A recent report revealed that intermittent energy restriction is comparable for the reduction of HbA1c with continuous energy restriction in patients with type 2 diabetes.62 While a report showed that continuous energy restriction reduced active baseline GLP‐1 from baseline,63 there is few report to reveal the effect of energy restriction on GLP‐1 secretion which means further studies are warranted to elucidate effect on GLP‐1 secretion in these important dietary interventions. This evidence concerns the gene GCG and type 2 diabetes mellitus.