For example, consumption of a fat‐rich meal with alcohol in subjects with T2DM results in suppression of GLP‐1 early in the postprandial phase.52 Further, reductions in the amount of sucrose in the meal were demonstrated to markedly decrease GLP‐1 secretion and were not restored by addition of sweeteners to compensate for the sweet taste in healthy individuals.53 Similarly, bread made from sourdough lowered GLP‐1 response when compared with multigrain or sprouted grain bread in subjects at risk for glucose intolerance54 (Table 2). This evidence concerns the gene GCG and type 2 diabetes mellitus.