GLP1R and type 2 diabetes mellitus: In patients with T2DM, adjusting the calorie balance in each meal with a high‐energy breakfast and low‐energy dinner has been shown to increase GLP‐1 levels, and decrease prandial hyperglycaemia compared to a high‐energy dinner and lower‐energy breakfast.58 Therefore, a change in meal timing with regard to calorie consumption could beneficially modulate GLP‐1 secretion.