Divided by function, these genes participate in metabolic pathways (Acsl1, Apoe1, Cebpa, Cs, Hk2, Lepr, and Lipe), insulin signaling (Igf1r, Ikbkb, Mtor, Pik3r1, Ptpn1, Socs3, and Irs2), T2DM (Adipoq, Hk2, Ikbkb, Mtor, Pik3r1, Socs3, and Irs2), adipokine signaling (Adipoq, Adipor2, Ikbkb, Jak2, Lepr, Mtor, Serpine1, Socs3, Stat3, and Irs2), innate immunity (Ikbkb, Pycard, and Irs2), inflammation (ccr4, Cxcr4, Ikbkb, Lta4h, and Pycard), apoptosis (Ikbkb, Jak2, Pycard, Serpine1, Socs3, and Irs2), or are markers of infiltrated leukocytes (Ccr4 and Crlf2) (Fig. 1, Fig. 2B). Here, IRS2 is linked to type 2 diabetes mellitus.