Divided by function, these genes were involved in metabolic pathways (Acsl1 and Hk2), insulin signaling (Igf1r, Ikbkb, Pik3r1, Rps6kb1, Socs3, and Irs2), T2DM (Hk2, Ikbkb, Pik3r1, Socs3, and Irs2), adipokine signaling (Adipor2, Ikbkb, Jak2, Serpine1, Socs3, Stat3, and Irs2), innate immunity (Ikbkb and Irs2), inflammation (Ikbkb and Lta4h), or apoptosis (Ikbkb, Jak2, Rps6kb1, Serpine1, Socs3, and Irs2) (Table 3 and Fig. 1, Fig. 2B). The gene discussed is PIK3R1; the disease is type 2 diabetes mellitus.