While this observation is in contrast with some reports, e.g., of a correlation between miR-146a and TLR4, IRAK1 in patients with coronary artery disease (18), others have observed reduced expression of IRAK1 by upregulation of miR-146a, e.g., in psoriasis (19) and in senescent cells (20). This evidence concerns the gene TLR4 and coronary artery disorder.